Carprofen Caplets
You said you wanted a more affordable pain relief option without compromising quality. We Listened.
Putney's Carprofen Caplets are a generic equivalent of Rimadyl® caplets. Carprofen is indicated in dogs for pain associated with canine osteoarthritis, and for controlling post-operative pain from certain surgeries.* Putney's Carprofen Caplets are less expensive than the brand equivalent, offering significant savings for dog owners and making it easier for them to afford the prescribed treatment and refills. The result: happy dogs and happy dog owners.
®Rimadyl is a registered trademark of Pfizer Animal Health.
*See Package Insert for complete indications, side effects, contraindications and other important product information.
Putney's Carprofen Caplets are available in 25 mg, 75 mg and 100 mg caplets (the same strengths as Rimadyl caplets) and are available in convenient 60 and 180 count bottles.
For more information, or to learn how to order Putney's Carprofen Caplets, call 1-866-683-0660 or email sales@putneyvet.com
If there is a distributor you would like to be able to request our products from, please let us know.
Product Information
Putney's Carprofen Caplets are approved by the FDA Center for Veterinary Medicine (CVM). Additional product information excerpted from CVM's Freedom of Information Summary (FOI) of the drug application is detailed below.
Target Animal Safety and Drug Effectiveness
Blood-Level Bioequivalence Study
FDA Conclusions
Manufacturer Details
Target Animal Safety and Drug Effectiveness
Bioequivalence data: Putney's Carprofen Caplets vs. Pfizer's Rimadyl (carprofen) caplets
Mean plasma levels of total carprofen (µg/mL) in dogs following oral administration at a dose rate of 2.0 mg carprofen/Ib bodyweight on one occasion.
Meets FDA's requirements of 80% - 125% for the 90% confidence intervals of the generic product versus pioneer product means for AUC (area under the curve) and CMAX (maximum concentration for all time periods).
Blood-Level Bioequivalence Study
A blood-level bioequivalence study was conducted to determine the comparative bioavailability of the generic caplet formulation and pioneer caplet formulation of carprofen.
Objective: The objective of this study was to determine the comparative blood-levels of Putney's 25 mg Carprofen Caplet (generic) and Pfizer Animal Health's 25 mg RIMADYL caplet (reference) in a two period crossover study in dogs.
Summary: The design of this study is a comparative bioavailability study using healthy adult dogs in a single-dose, two-period, two sequence, crossover design with randomization of experimental units to two sequences. Fourteen dogs (7 males and 7 females) were blocked by weight without regard to sex and, within block, randomly assigned to either of two treatment sequences where the treatment sequences were reference followed by generic or vice versa. A 35-day washout interval separated the two periods. Blood samples were collected at approximately 17 hours before dose administration, and at 0.25, 0.5, 0.75, 1.0, 1.33, 1.66, 2.0, 3.0, 4.0, 6.0, 8.0, 12.0, 18.0, 24.0, 48.0 and 72.0 hours following dose administration for the measurement of carprofen in plasma.
Results: The area under the curve was compared using the trapezoidal rule from time 0 out to the last sampling time associated with quantifiable drug concentrations (AUC). The natural logarithm of AUC was computed and used as the variable for analysis. The maximum concentration measured for all time periods (CMAX) was determined and the natural logarithm of CMAX was computed and used as the variable for analysis.
The criteria for determining bioequivalence, as described in CVM's Bioequivalence Guidance is to construct a 90% confidence interval about the difference of the two means, generic minus pioneer, based on the log scale of AUC and CMAX and then take the anti-log of the confidence limits multiplied by 100. The resulting bounds should be between 80.00% and 125.00%. As seen in the table below both AUC and CMAX fall within those bounds.
| Variable | Putney Mean | Pfizer Mean | Lower Bound | Upper Bound |
|---|---|---|---|---|
| AUC (µg/mL*hr) | 403.2* | 375.7* | 100.38% | 114.74% |
| CMAX (µg/mL) | 37.7* | 37.1* | 86.34% | 119.85% |
| TMAX(hr) | 3.43 | 2.62 | NA | NA |
* Geometric Mean
Arithmetic Mean
The variable time to maximum concentration (TMAX) is permitted to be interpreted by clinical judgment. In this case, there is no reason to expect the difference in TMAX will affect the efficacy of the drug, since both AUC and CMAX are bioequivalent and the product is administered as a single dose. Therefore, the study objective to determine the bioequivalence of the generic and pioneer carprofen caplets was achieved.
The FDA concluded that the ANADA satisfies FDA requirements for drug approval and demonstrates that Putney's Carprofen Caplets, when used under the proposed conditions of use, are safe and effective for the labeled indications.
For more information, view the FDA's CVM Freedom of Information Summary pertaining to Putney's Carprofen Caplets (ANADA #200-498) at http://www.fda.gov/downloads/AnimalVeterinary/Products/ApprovedAnimalDrugProducts/FOIADrugSummaries/UCM167678.pdf
Distribution
Putney’s Carprofen Caplets are available through selected distributors, listed below. Please contact them directly to place your order.
If there is a distributor not listed here that you’d like to be able to request our products from, please let us know. Call 1-866-683-0660 or email sales@putneyvet.com.
 |
Valparaiso, IN: 800.441.2309 www.hauserpharmaceutical.com |
 |
Florida, 1-800-399-8387 www.amatheon.com/ |
 |
Redondo Beach, CA: 800.438.2568 www.dvmed.com |
 |
800.998.4661 www.firstveterinarysupply.com |
 |
877-270-5074 www.ivescollc.com |
 |
South Carolina: 1-800-845-0411 https://www.merrittvet.com/ |
 |
800-233-0210 www.pennvet.com |
 |
800.777.7241, press 0 www.pcivet.com |
 |
Portland, OR: 877.738.8883 www.vetsource.com |
Home Delivery
Many hospitals partner with a veterinary-sponsored home delivery service to maintain proper oversight of pets’ prescriptions, and protect revenue and margins. Doctors can not only prescribe medications from companies committed to keeping their products out of online pharmacies that circumvent the veterinarian, but also provide their pet owners the convenience of home delivery—to help support compliance.
Veterinary hospitals must partner with a veterinary-sponsored pharmacy in order for their pet owners to be able to take advantage of the home delivery option. Putney’s Carprofen Caplets are now available through the following home delivery pharmacies:
 |
Portland, OR: Hospital Resources: 877.738.8883 Pet Owner Resources: 877.738.4443 www.vetsource.com |